溶质载体家族1成员2基因（SLC1A2）rs3794087变异与偏头痛风险
SLC1A2 rs3794087 variant and risk for migraine.
作者信息
García-Martín Elena, Martínez Carmen, Serrador Mercedes, Alonso-Navarro Hortensia, Navacerrada Francisco, Agúndez José A G, Jiménez-Jiménez Félix Javier
机构信息
Department of Biochemistry & Molecular Biology, University of Extremadura, Cáceres, Spain.
Department of Pharmacology, University of Extremadura, Badajoz, Spain.
出版信息
J Neurol Sci. 2014 Mar 15;338(1-2):92-5. doi: 10.1016/j.jns.2013.12.022. Epub 2013 Dec 18.
BACKGROUND/OBJECTIVES: Glutamate has been implicated in the pathogenesis of migraine. We investigated the possible association between the polymorphism rs3794087 in the SLC1A2 gene (EATT2 or GLT-1; chromosome 11p13-p12 involved in glutamate transport) and the risk for migraine and for triggering migraine attacks by alcohol.
METHODS
We studied the frequency of the rs3794087 genotypes and allelic variants in 197 patients with migraine and 308 healthy controls using a TaqMan-based qPCR assay.
RESULTS
The frequencies of the rs3794087 genotypes and alleles were similar in patients with migraine and controls, and were unrelated with the age of onset of migraine, gender, presence or absence of aura, or family history of migraine
CONCLUSION
rs3794087 genotype and allelic variants were not related with the risk for migraine in Caucasian Spanish people.
背景/目的：谷氨酸已被认为与偏头痛的发病机制有关。我们研究了溶质载体家族1A成员2基因（EATT2或GLT - 1；位于11号染色体p13 - p12，参与谷氨酸转运）中的单核苷酸多态性rs3794087与偏头痛风险以及酒精引发偏头痛发作之间的可能关联。
方法
我们使用基于TaqMan的定量聚合酶链反应分析法，研究了197例偏头痛患者和308例健康对照者中rs3794087基因型和等位基因变体的频率。
结果
偏头痛患者和对照者中rs3794087基因型和等位基因的频率相似，且与偏头痛的发病年龄、性别、有无先兆或偏头痛家族史无关。
结论
在西班牙白种人中，rs3794087基因型和等位基因变体与偏头痛风险无关。
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