多巴胺受体 3 (DRD3) 多态性与偏头痛风险。
Dopamine receptor 3 (DRD3) polymorphism and risk for migraine.
机构信息
Biochemistry & Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain.
Pharmacology & Psychiatry, Medical School, University of Extremadura, Badajoz, Spain.
出版信息
Eur J Neurol. 2010 Sep;17(9):1220-1223. doi: 10.1111/j.1468-1331.2010.02988.x. Epub 2010 Mar 1.
BACKGROUND/OBJECTIVES: Dopamine has been implicated in the pathogenesis of migraine. We investigated the possible association between the polymorphism 312G>A (rs6280) in the DRD3 gene(essential tremor 1-ETM1- locus, chromosome 3q13) and the risk for migraine and for triggering migraine attacks by alcohol.
METHODS
We studied the frequency of the DRD3 genotypes and allelic variants in 197 patients with migraine and 282 healthy controls using a polymerase chain reaction and MlsI-restriction fragment length polymorphisms method.
RESULTS
The frequencies of the DRD3 genotypes and DRD3Gly9 were similar in patients with migraine and controls and were unrelated to the age of onset of migraine, gender, family history of migraine and triggering of migraine attacks by alcohol. The frequency of the genotype DRD3Gly9Gly9 was significantly higher in patients with migraine with aura when compared with patients with migraine without aura, but not with controls.
CONCLUSION
DRD3 genotype and allelic variants were not related to the risk for migraine in Caucasian Spanish people.
背景/目的：多巴胺在偏头痛的发病机制中起作用。我们研究了 DRD3 基因（特发性震颤 1 号 ET1- 基因座，3 号染色体 q13）中 312G>A（rs6280）多态性与偏头痛风险以及酒精诱发偏头痛发作风险之间的可能关联。
方法
我们使用聚合酶链反应和 MlsI 限制片段长度多态性方法研究了 197 例偏头痛患者和 282 例健康对照者的 DRD3 基因型和等位基因变异的频率。
结果
偏头痛患者和对照组的 DRD3 基因型和 DRD3Gly9 频率相似，与偏头痛的发病年龄、性别、偏头痛家族史和酒精诱发偏头痛发作无关。与无先兆偏头痛患者相比，有先兆偏头痛患者的 DRD3Gly9Gly9 基因型频率显著升高，但与对照组相比则无差异。
结论
在西班牙白种人群中，DRD3 基因型和等位基因变异与偏头痛风险无关。
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