研究黑腹果蝇的昼夜节律。
Studying circadian rhythms in Drosophila melanogaster.
作者信息
Tataroglu Ozgur, Emery Patrick
机构信息
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
出版信息
Methods. 2014 Jun 15;68(1):140-50. doi: 10.1016/j.ymeth.2014.01.001. Epub 2014 Jan 9.
Circadian rhythms have a profound influence on most bodily functions: from metabolism to complex behaviors. They ensure that all these biological processes are optimized with the time-of-day. They are generated by endogenous molecular oscillators that have a period that closely, but not exactly, matches day length. These molecular clocks are synchronized by environmental cycles such as light intensity and temperature. Drosophila melanogaster has been a model organism of choice to understand genetically, molecularly and at the level of neural circuits how circadian rhythms are generated, how they are synchronized by environmental cues, and how they drive behavioral cycles such as locomotor rhythms. This review will cover a wide range of techniques that have been instrumental to our understanding of Drosophila circadian rhythms, and that are essential for current and future research.
昼夜节律对大多数身体功能有着深远影响
从新陈代谢到复杂行为。它们确保所有这些生物过程在一天中的不同时间得到优化。它们由内源性分子振荡器产生，其周期与白天长度紧密但不完全匹配。这些分子时钟通过诸如光照强度和温度等环境周期进行同步。黑腹果蝇一直是研究昼夜节律如何产生、如何通过环境线索同步以及如何驱动诸如运动节律等行为周期的遗传学、分子学和神经回路层面的首选模式生物。本综述将涵盖一系列对我们理解果蝇昼夜节律至关重要且对当前和未来研究必不可少的技术。
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