Widen S G, Papaconstantinou J
Mol Cell Biol. 1987 Jul;7(7):2606-9. doi: 10.1128/mcb.7.7.2606-2609.1987.
alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.
甲胎蛋白（AFP）是一种肝脏特异性蛋白，在小鼠肝癌细胞（BWTG3）与大鼠成纤维细胞（JF1）融合形成的体细胞杂种中被消除。我们的研究表明，这些体细胞杂种中小鼠AFP表达的消除可能涉及至少两个顺式作用调节域，即增强子元件和一个组织特异性启动子区域，它们位于AFP基因的5'侧翼区域。
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