Solntseva E I
Neirofiziologiia. 1987;19(3):413-7.
The effects of quinine on the peak amplitude and relaxation of calcium current (ICa) were examined on isolated unidentified snail neurons. Quinine (1 X 10(-5)-5 X 10(-4) mol/l) reversibly slowed the relaxation of ICa in a dose-dependent manner (early effect) and suppressed the peak amplitude of ICa in a dose-dependent and time-dependent manner (delayed effect). Quinine induced a shift of the current-voltage relationship for peak ICa by 5-10 mV in the hyperpolarizing direction. A half inhibition of ICa peak amplitude was induced by 6 X 10(-5) mol/l quinine. The results show that quinine is an effective inhibitor of calcium channels in snail neurons.
在分离出的未鉴定蜗牛神经元上研究了奎宁对钙电流（ICa）峰值幅度和松弛的影响。奎宁（1×10⁻⁵ - 5×10⁻⁴ mol/L）以剂量依赖性方式可逆地减慢ICa的松弛（早期效应），并以剂量依赖性和时间依赖性方式抑制ICa的峰值幅度（延迟效应）。奎宁使ICa峰值的电流 - 电压关系向超极化方向偏移5 - 10 mV。6×10⁻⁵ mol/L的奎宁可诱导ICa峰值幅度的半数抑制。结果表明，奎宁是蜗牛神经元中钙通道的有效抑制剂。
