Romao Susana, Münz Christian
Viral Immunobiology; Institute of Experimental Immunology; University of Zürich; Zürich, Switzerland.
Autophagy. 2014 Mar;10(3):526-8. doi: 10.4161/auto.27606. Epub 2014 Jan 7.
A recent report from our group has described that upon engulfment of pathogens, a subset of phagosomes is formed to preserve antigens for prolonged presentation on MHC class II molecules. The distinctive feature of these particular vesicles is their coating with LC3/Atg8, a key component of the autophagy machinery. Here we discuss the possible outcomes of LC3-associated phagocytosis and its implications in the context of immunity.
我们团队最近的一份报告描述了在吞噬病原体时,会形成一部分吞噬体来保存抗原,以便在MHC II类分子上进行长时间的呈递。这些特殊囊泡的独特特征是它们被自噬机制的关键成分LC3/Atg8所包裹。在这里,我们讨论了LC3相关吞噬作用的可能结果及其在免疫背景下的意义。