Pharmacological analysis of 125I-Bolton and Hunter labelled eledoisin binding sites in rat spinal cord by quantitative autoradiography. - Suppr | 超能文献

Pharmacological analysis of 125I-Bolton and Hunter labelled eledoisin binding sites in rat spinal cord by quantitative autoradiography.

作者信息

Hunter J C, Kilpatrick G J, Brown J R

出版信息

Neurosci Lett. 1987 Jul 9;78(1):12-6. doi: 10.1016/0304-3940(87)90553-2.

DOI:10.1016/0304-3940(87)90553-2

Abstract

Using the technique of quantitative autoradiography it has been possible to investigate and compare the pharmacological characteristics of 125I-Bolton-Hunter conjugated eledoisin (125I-BHE) binding sites in rat spinal cord with those in the rat cortex. 125I-BHE specific binding sites were discretely localised in the outer layers of the rat spinal cord. The rank order of affinity of unlabelled tachykinins in competing for 125I-BHE specific binding sites in rat spinal cord (NKB greater than ELE greater than NKA greater than SP) was identical to that found in the rat cortex suggesting the presence of 'NK-3 like' receptors in rat dorsal horn.

摘要

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