Hoffmann H, Siebeck M, Thetter O, Fink E, Philapitsch A
Prog Clin Biol Res. 1987;236A:159-64.
Infusion of dextran sulfate in pigs rapidly activates the intrinsic cascade of the coagulation system including plasma prokallikrein and leads to release of kinin by limited proteolysis of kininogen. In this model, strong suppression of the DXS-induced activation of the plasma kallikrein-kinin system is seen at plasma aprotinin levels above 400 KIU/ml and C1INH levels above 4 U/ml.
给猪输注硫酸葡聚糖会迅速激活凝血系统的内源性级联反应，包括血浆前激肽释放酶，并通过激肽原的有限蛋白水解导致激肽释放。在该模型中，当血浆抑肽酶水平高于400 KIU/ml且C1INH水平高于4 U/ml时，可观察到对硫酸葡聚糖诱导的血浆激肽释放酶-激肽系统激活的强烈抑制。
