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隆突切除术。

Carinal resection.

作者信息

Spaggiari Lorenzo, Petrella Francesco, Galetta Domenico

机构信息

Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy.

出版信息

Multimed Man Cardiothorac Surg. 2012 Jan 1;2012:mms001. doi: 10.1093/mmcts/mms001.

Abstract

Carinal resection is defined as the resection of tracheo-bronchial bifurcation, with or without lung parenchyma resection. It represents one of the most challenging areas of airway resection and reconstruction, basically due to the variability in the location and extent of the lesions. Main indications for this procedure are primary tumours of the carina or the distal trachea or, more frequently, bronchogenic carcinoma with carinal involvement. Very different approaches and reconstruction techniques have been experimentally and clinically described in the last 50 years, with some corner stone procedures in the history of modern thoracic surgery. Despite many technical and oncological difficulties encountered in this field, encouraging results have been reported in recent series, in particular an excellent 5-year survival rate of 50% in pN0 patients suffering form carinal infiltration form lung cancer. Several aspects of the multimodality approach to neoplastic carinal involvement still remain debatable like radio-chemotherapeutic approach instead of the extremely rare left carinal pneumonectomy as well as the role of induction treatments before embarking in such demanding procedures, according to the -pathological nodal status.

摘要

隆突切除定义为气管支气管分叉处的切除,可伴有或不伴有肺实质切除。它是气道切除与重建中最具挑战性的领域之一,主要原因是病变的位置和范围存在差异。该手术的主要适应证是隆突或气管远端的原发性肿瘤,或者更常见的是累及隆突的支气管源性癌。在过去50年里,已经在实验和临床方面描述了非常不同的手术入路和重建技术,其中一些是现代胸外科历史上的关键手术。尽管在该领域遇到了许多技术和肿瘤学上的困难,但最近的系列报道显示了令人鼓舞的结果,特别是对于因肺癌隆突浸润而接受手术的pN0患者,其5年生存率高达50%,效果极佳。对于肿瘤累及隆突的多模式治疗方法的几个方面仍存在争议,例如放化疗方法替代极为罕见的左隆突全肺切除术,以及根据病理淋巴结状态,在进行如此复杂的手术之前诱导治疗的作用。

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