Cikirikcioglu Mustafa, Cherian Sanjay, Kalangos Afksendiyos
Division of Cardiovascular Surgery, University Hospitals and Medical Faculty of Geneva, Switzerland.
Multimed Man Cardiothorac Surg. 2012 Jan 1;2012:mms019. doi: 10.1093/mmcts/mms019.
The final step in mitral valve repair is usually the implantation of an annuloplasty ring which remodels the dilated annulus and improves the long-term durability of repair. Conventional annuloplasty rings remain as a permanent foreign body on the atrio-ventricular annulus, thus presenting an increased risk for thromboembolic complications. Furthermore, currently available conventional rings are adapted for the adult population, with no annuloplasty ring specifically developed for the paediatric population. A new intra-annular ring that undergoes gradual degradation by hydrolysis has been developed for use both in adults and in children. The resultant inflammatory reaction induces fibrosis, thereby remodelling the posterior mitral annulus. Contrary to the conventional rings that are implanted 'onto' the annulus, the intra-annular ring is implanted 'into' the annulus, and hence prevents direct contact with the circulating blood, thereby reducing the risk of thrombo-embolic complications and negating the need for anticoagulation. This annuloplasty ring also permits normal growth of the valve orifice in the paediatric population. This article aims to present the intra-annular implantation technique and the rationale for a biodegradable annuloplasty ring in mitral valve repair.
二尖瓣修复的最后一步通常是植入瓣环成形环,该环可重塑扩张的瓣环并提高修复的长期耐久性。传统的瓣环成形环作为异物永久留在房室瓣环上,因此血栓栓塞并发症的风险增加。此外,目前可用的传统环适用于成人,没有专门为儿科人群开发的瓣环成形环。一种通过水解逐渐降解的新型瓣内环已被开发出来,可用于成人和儿童。由此产生的炎症反应会诱导纤维化,从而重塑二尖瓣后瓣环。与植入在瓣环“之上”的传统环不同,瓣内环是植入在瓣环“之内”,因此可防止与循环血液直接接触,从而降低血栓栓塞并发症的风险并消除抗凝的必要性。这种瓣环成形环还允许儿科人群的瓣膜口正常生长。本文旨在介绍瓣内环植入技术以及二尖瓣修复中可生物降解瓣环成形环的原理。