Tomino Y, Sakai H, Basolo B, Aarons I, Clarkson A R
Tokai J Exp Clin Med. 1986 Oct;11(4):235-9.
Correlation of paramesangial deposits ("hemispherical body") and glomerular sclerosis and/or hyalinosis was examined by light microscopical analysis in 40 patients of IgA nephropathy. Correlation of paramesangial deposits and intensity of IgA or C3 deposition in glomeruli was also evaluated in these patients. The number of paramesangial deposits was markedly increased in patients with moderate and advanced stages of IgA nephropathy who showed marked glomerular sclerosis and/or hyalinosis. There was a significant correlation between the number of paramesangial deposits and the intensity of IgA deposits in glomeruli. It is suggested that the accumulation of paramesangial deposits might induce severe glomerular injuries such as glomerular sclerosis and/or hyalinosis.
通过光学显微镜分析，对40例IgA肾病患者系膜旁沉积物（“半球体”）与肾小球硬化和/或玻璃样变的相关性进行了研究。同时也评估了这些患者系膜旁沉积物与肾小球中IgA或C3沉积强度的相关性。在出现明显肾小球硬化和/或玻璃样变的IgA肾病中、晚期患者中，系膜旁沉积物的数量显著增加。系膜旁沉积物的数量与肾小球中IgA沉积强度之间存在显著相关性。提示系膜旁沉积物的积聚可能会导致严重的肾小球损伤，如肾小球硬化和/或玻璃样变。
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