对IgA肾病患者肾小球中α2-纤溶酶抑制剂（α2-PI）的免疫荧光研究。
Immunofluorescent studies on alpha 2-plasmin inhibitor (alpha 2-PI) in glomeruli from patients with IgA nephropathy.
作者信息
Miura M, Tomino Y, Yagame M, Endoh M, Suga T, Nomoto Y, Sakai H
出版信息
Clin Exp Immunol. 1985 Nov;62(2):380-6.
Detection of alpha 2-plasmin inhibitor (alpha 2-PI) and/or fibrinogen in glomeruli by immunofluorescence in 26 patients with IgA nephropathy was described. The present study showed that glomerular injuries such as glomerular adhesion to Bowman's capsule and the cellular and/or fibrous crescent were predominantly observed in glomeruli with alpha 2-PI and/or fibrinogen deposits in patients with IgA nephropathy. Alpha 2-PI coexisted with fibrinogen in glomeruli from patients with IgA nephropathy. It was postulated that the deposition of alpha 2-PI in vivo might lead to the accumulation of glomerular fibrinogen deposits in patients with IgA nephropathy. It was suggested that the depositions of alpha 2-PI and/or fibrinogen in glomeruli may be one of the exacerbative factors in glomeruli from patients with IgA nephropathy.
描述了通过免疫荧光法在26例IgA肾病患者中检测肾小球中的α2-纤溶酶抑制剂（α2-PI）和/或纤维蛋白原。本研究表明，在IgA肾病患者中，肾小球与鲍曼囊粘连以及细胞性和/或纤维性新月体等肾小球损伤主要见于有α2-PI和/或纤维蛋白原沉积的肾小球。在IgA肾病患者的肾小球中，α2-PI与纤维蛋白原共存。据推测，体内α2-PI的沉积可能导致IgA肾病患者肾小球纤维蛋白原沉积的积累。提示α2-PI和/或纤维蛋白原在肾小球中的沉积可能是IgA肾病患者肾小球病变加重的因素之一。
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