赞比亚患者中APOE、MTHFR和ACE基因多态性与中风的关联
Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients.
作者信息
Atadzhanov Masharip, Mwaba Mwila H, Mukomena Patrice N, Lakhi Shabir, Rayaprolu Sruti, Ross Owen A, Meschia James F
机构信息
Department of Internal Medicine, School of Medicine, University of Zambia, Lusaka, Zambia; Departments of.
Neuroscience.
出版信息
Neurol Int. 2013 Nov 11;5(4):e20. doi: 10.4081/ni.2013.e20. eCollection 2013.
Abstract
The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.
摘要
本研究的目的是调查载脂蛋白E（APOE）、亚甲基四氢叶酸还原酶（MTHFR）和血管紧张素转换酶（ACE）基因多态性与赞比亚人群中风的关联。我们分析了41例中风患者和116例均为赞比亚裔的对照者，以研究APOE、MTHFR和ACE基因多态性的基因型与中风之间的关联。APOE ε2ε4基因型显示出血性中风风险增加（P<0.05），缺血性中风风险也较高（P=0.05）。赞比亚人群中完全不存在APOE ε2ε2和MTHFR TT基因型。在分析中风、中风亚型与基因型之间的关系时，其他基因变异在病例组和对照组之间的差异不显著。我们发现APOE基因座的遗传变异会影响中风易感性。在赞比亚人群中，未观察到MTHFR和ACE基因型与中风之间有可检测到的关联。
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