Arai Rie, Itoh Shiori, Masatsugu Asako, Ohta Miyuki, Shintaku Masayuki, Masatsugu Ken, Horiguchi Yuji
Department of Dermatology, Osaka Saiseikai Izuo Hospital, Kitamura 3-4-5, Taisho-ku, Osaka 551-0032, Japan.
Cutis. 2013 Dec;92(6):299-302.
It is well known that patients with diabetes mellitus (DM) may demonstrate skin manifestations, or dermadromes, due to disease-related metabolic, vascular, neurologic, and/or immunologic disturbances; however, the pathogenesis of some of these manifestations remains unknown. Xanthomas often are associated with increased levels of serum cholesterol and/or triglycerides and therefore can present as a dermadrome in patients with a history of uncontrolled DM and hyperlipidemia. The presence of tender lesions in this patient population can indicate a diagnosis of perineural xanthoma. We report a case of perineural xanthoma arising in a patient with type 2 DM and hyperlipidemia.
众所周知，糖尿病（DM）患者可能会因疾病相关的代谢、血管、神经和/或免疫紊乱而出现皮肤表现或皮肤综合征；然而，其中一些表现的发病机制尚不清楚。黄瘤通常与血清胆固醇和/或甘油三酯水平升高有关，因此在有未控制的糖尿病和高脂血症病史的患者中可表现为一种皮肤综合征。在这一患者群体中出现压痛性病变可能提示诊断为神经周围黄瘤。我们报告一例2型糖尿病和高脂血症患者发生神经周围黄瘤的病例。
