Liu Yang, Jiang Chen
Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy, Fudan University, Shanghai 201203, China.
Yao Xue Xue Bao. 2013 Oct;48(10):1532-43.
The blood-brain barrier (BBB) exerts its central nervous system (CNS) protective function as it hinders the delivery of diagnostic and therapeutic agents to the brain. With the development of nanotechnology during the last thirty years, the nanocarriers for delivering drugs make it possible to transport drugs across the BBB. The brain-targeted drug delivery system usually consists of two parts: nanocarriers and brain-targeted strategies. In this review, several kinds of nanocarriers are introduced for brain-targeted drug delivery. We focus on several possible strategies for brain-targeting and comment on their advantages and disadvantages in application.
血脑屏障（BBB）发挥其对中枢神经系统（CNS）的保护作用，因为它阻碍诊断和治疗药物向大脑的递送。在过去三十年中，随着纳米技术的发展，用于递送药物的纳米载体使药物能够穿越血脑屏障进行运输成为可能。脑靶向给药系统通常由两部分组成：纳米载体和脑靶向策略。在本综述中，介绍了几种用于脑靶向给药的纳米载体。我们重点关注几种可能的脑靶向策略，并对其在应用中的优缺点进行评论。
