Key Laboratory of Smart Drug Delivery (Fudan University) Ministry of Education, Shanghai, China
Pharm Res. 2013 Oct;30(10):2485-98. doi: 10.1007/s11095-013-1122-4.
Major central nervous system (CNS) disorders, including brain tumors, Alzheimer’s disease, Parkinson’s disease, and stroke, are significant threats to human health. Although impressive advances in the treatment of CNS disorders have been made during the past few decades, the success rates are still moderate if not poor. The blood–brain barrier (BBB) hampers the access of systemically administered drugs to the brain. The development of nanotechnology provides powerful tools to deliver therapeutics to target sites. Anchoring them with specific ligands can endow the nano-therapeutics with the appropriate properties to circumvent the BBB. In this review, the potential nanotechnology-based targeted drug delivery strategies for different CNS disorders are described. The limitations and future directions of brain-targeted delivery systems are also discussed.
主要的中枢神经系统（CNS）疾病，包括脑肿瘤、阿尔茨海默病、帕金森病和中风，是对人类健康的重大威胁。尽管在过去几十年中，中枢神经系统疾病的治疗取得了令人瞩目的进展，但成功率仍然不高。血脑屏障（BBB）阻碍了系统性给予的药物进入大脑。纳米技术的发展为将治疗剂递送到靶部位提供了强大的工具。通过将它们与特定的配体结合，可以赋予纳米治疗剂适当的特性来绕过 BBB。在这篇综述中，描述了不同中枢神经系统疾病的基于纳米技术的靶向药物递送策略的潜力。还讨论了脑靶向递药系统的局限性和未来方向。
