[滋养层β1-糖蛋白与胎盘α2-微球蛋白体外免疫抑制特性的比较研究]
[Comparative study of the immunosuppressive properties of trophoblastic beta 1-glycoprotein and placental alpha 2-microglobulin in vitro].
作者信息
Gulianskiĭ L N, Petrunin D D, Fedorov G N, Tatarinov Iu S
出版信息
Biull Eksp Biol Med. 1987 Jul;104(7):65-7.
PMID:2441773
Abstract
It has been shown that trophoblastic beta 1-glycoprotein (TBG) and placental alpha 2-microglobulin (PAMG-2) in concentrations 60-120 micrograms/ml suppresses both the inductive and proliferative phase of unidirectional mixed lymphocyte reaction in mice, as well as proliferative responses to phytohemagglutinin or pokeweed mitogen. TBG protein was more effective. The proteins were not toxic for lymphocytes.
摘要
研究表明，浓度为60 - 120微克/毫升的滋养层β1 -糖蛋白（TBG）和胎盘α2 -微球蛋白（PAMG - 2）可抑制小鼠单向混合淋巴细胞反应的诱导期和增殖期，以及对植物血凝素或商陆有丝分裂原的增殖反应。TBG蛋白的效果更显著。这些蛋白质对淋巴细胞无毒。
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