Wang Min, Yu Li, Zhou Ling, Zhang Wen-ying
Department of Obstetrics & Gynecology, No. 306 Hospital of PLA, Beijing 100101, China.
Department of Obstetrics & Gynecology, No. 306 Hospital of PLA, Beijing 100101, China. Email:
Zhonghua Yi Xue Za Zhi. 2013 Oct 22;93(39):3128-30.
To evaluate the efficacy of laparoscopic conservative surgery plus gonadotropin-releasing hormone agonist (GnRH-a) in the treatment of endometriosis through meta-analysis.
Six randomized controlled clinical trials comparing laparoscopic conservative surgery plus GnRH-a versus placebo or no treatment for endometriosis were retrieved. Meta-analysis was conducted to estimate the efficacy.
A total of 477 patients were included. Among them, 233 patients received laparoscopic conservative surgery plus GnRH-a while another 244 laparoscopic surgery alone. The results of meta-analysis showed that laparoscopic conservative surgery plus GnRH-a could decrease the recurrence of pain symptoms (P < 0.05), but it could not increase the pregnancy rate of infertility associated with endometriosis (P > 0.05). Furthermore the combined regiment could better improve clinical symptoms than placebo.
Laparoscopic conservative surgery plus GnRH-a could decrease the recurrence of pain symptoms associated with endometriosis, but it failed to increase the pregnancy rate of infertility.
通过荟萃分析评估腹腔镜保守手术联合促性腺激素释放激素激动剂（GnRH-a）治疗子宫内膜异位症的疗效。
检索了六项比较腹腔镜保守手术联合GnRH-a与安慰剂或不治疗子宫内膜异位症的随机对照临床试验。进行荟萃分析以评估疗效。
共纳入477例患者。其中，233例患者接受腹腔镜保守手术联合GnRH-a治疗，另外244例仅接受腹腔镜手术。荟萃分析结果显示，腹腔镜保守手术联合GnRH-a可降低疼痛症状复发率（P < 0.05），但不能提高子宫内膜异位症相关性不孕的妊娠率（P > 0.05）。此外，联合治疗方案比安慰剂能更好地改善临床症状。
腹腔镜保守手术联合GnRH-a可降低子宫内膜异位症相关疼痛症状的复发率，但未能提高不孕的妊娠率。
