通过钯催化羰基化反应由环氧化物和2-溴苯酚区域选择性合成2,3-二氢苯并二氧杂环庚酮
Regioselective synthesis of 2,3-dihydrobenzodioxepinones from epoxides and 2-bromophenols via palladium-catalyzed carbonylation.
作者信息
Li Haoquan, Spannenberg Anke, Neumann Helfried, Beller Matthias, Wu Xiao-Feng
机构信息
Leibniz-Institut für Katalyse e.V., Albert Einstein Straße, 29a, 18059 Rostock, Germany.
出版信息
Chem Commun (Camb). 2014 Feb 28;50(17):2114-6. doi: 10.1039/c3cc48490d. Epub 2014 Jan 13.
PMID:24419092
Abstract
A highly regioselective cascade synthesis of 2,3-dihydrobenzodioxepinone from 2-bromophenols and epoxides has been developed. The reactions go through nucleophilic ring-opening of epoxides and subsequent palladium-catalyzed intramolecular alkoxylcarbonylation.
摘要
已开发出一种从2-溴苯酚和环氧化物高效区域选择性级联合成2,3-二氢苯并二氧杂环庚酮的方法。该反应通过环氧化物的亲核开环以及随后钯催化的分子内烷氧基羰基化反应进行。
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