8-羟基喹啉对尿苷摄取和掺入 RNA 的影响。
Effect of 8-hydroxyquinoline on the uptake of uridine and incorporation into RNA.
机构信息
Institut für Biologie II, Lehrstuhl für Genetik, Universität Tübingen, Auf der Morgenstelle 28, D-7400, Tübingen, Federal Republic of Germany.
出版信息
Planta. 1977 Jan;134(2):155-7. doi: 10.1007/BF00384965.
PMID:24419694
Abstract
8-hydroxyquinoline has been previously used as an inhibitor in studies on porphyrin metabolism, where it is thought to act by chelating iron. It is shown that this compound also rapidly inhibits uridine uptake of seedlings or cotyledons of the crucifer Matthiola incana R.Br. RNA synthesis is also affected but the inhibition is not as severe as reported for fission yeast.
摘要
8-羟基喹啉以前曾被用作卟啉代谢研究中的抑制剂，据认为它通过螯合铁起作用。研究表明，该化合物还能迅速抑制十字花科植物 Matthiola incana R.Br. 的幼苗或子叶的尿苷摄取。RNA 合成也受到影响，但抑制程度不如裂殖酵母报道的那么严重。
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