Lin Cheng-Huang, He Yi-San, Lin Chien-Hung, Fan Gang-Ting, Chen Hsin-Kai
Department of Chemistry, National Taiwan Normal University.
Anal Sci. 2014;30(1):183-91. doi: 10.2116/analsci.30.183.
This mini-review introduces a general understanding of the use of a milli-whistle as a gas chromatography (GC) detector in gas analysis, including our research on the methodology and theory associated with a number of different related applications. The milli-whistle is connected to the outlet of a GC capillary, and when the eluted gases and the GC carrier gas pass through it, a sound with a fundamental frequency is produced. The sound wave can be picked up by a microphone or an accelerometer, and after a fast Fourier transform, the online data obtained for frequency-change vs. retention time constitute a new method for detecting gases. The first part of this review discusses the fundamentals of the milli-whistle. Some modifications are also discussed, including various types of whistles and an attempt to maximize the sensitivity and stability of the method. The second part then focuses on several practical applications, including an analysis of hydrogen released from ammonia borane, inorganic gases produced from fireworks, the CO2/O2 ratio from expired human breath and a purity test for alcohols. These studies show that the GC-whistle method has great potential for use as a fast sampling ionization method, and for the direct analysis of biological and chemical samples at under ambient conditions.
本综述介绍了对毫微哨作为气相色谱（GC）检测器在气体分析中的应用的一般理解，包括我们对与许多不同相关应用相关的方法和理论的研究。毫微哨连接到GC毛细管的出口，当洗脱气体和GC载气通过它时，会产生具有基频的声音。声波可以由麦克风或加速度计拾取，经过快速傅里叶变换后，频率变化与保留时间的在线数据构成了一种检测气体的新方法。本综述的第一部分讨论了毫微哨的基本原理。还讨论了一些改进，包括各种类型的哨以及提高该方法灵敏度和稳定性的尝试。第二部分则重点介绍了几个实际应用，包括对硼氨烷释放的氢气的分析、烟花产生的无机气体的分析、呼出气体中的CO2/O2比率以及酒精的纯度测试。这些研究表明，GC哨方法作为一种快速采样电离方法以及在环境条件下直接分析生物和化学样品具有巨大潜力。
