Habre-Hallage P, Dricot L, Hermoye L, Reychler H, van Steenberghe D, Jacobs R, Grandin C B
Department of Prosthodontics, Faculty of Dentistry, Saint Joseph University, Campus of Medical Sciences, B.P. 11-5076, Damascus Road, Beirut, Lebanon,
Clin Oral Investig. 2014 Nov;18(8):1949-61. doi: 10.1007/s00784-013-1174-1. Epub 2014 Jan 14.
To describe the normal cortical projections of periodontal mechanoreceptors.
A device using von Frey filaments delivered 1-Hz punctate tactile stimuli to the teeth during fMRI. In a block design paradigm, tooth (T) 11 and T13 were stimulated in ten volunteers and T21 and T23 in ten other subjects. Random-effect group analyses were performed for each tooth, and differences between teeth were examined using ANOVA.
The parietal operculum (S2) was activated bilaterally for all teeth; the postcentral gyrus (S1) was activated bilaterally for T21 and T23 and contralaterally for T11 and T13. In the second-level analysis including the four teeth, we found five clusters: bilateral S1 and S2, and left inferior frontal gyrus, with no difference between teeth in somatosensory areas. However, the ANOVA performed on the S1 clusters found separately in each tooth showed that S1 activation was more contralateral for the canines.
One-hertz mechanical stimulation activates periodontal mechanoreceptors and elicits bilateral cortical activity in S1 and S2, with a double representation in S2, namely in OP1 and OP4.
The cortical somatotopy of periodontal mechanoreceptors is poorly described. These findings may serve as normal reference to further explore the cortical plasticity induced by periodontal or neurological diseases.
描述牙周机械感受器的正常皮质投射。
一种使用von Frey细丝的装置在功能磁共振成像（fMRI）期间向牙齿施加1赫兹点状触觉刺激。在组块设计范式中，对10名志愿者的11号牙（T11）和13号牙（T13）以及另外10名受试者的21号牙（T21）和23号牙进行刺激。对每颗牙齿进行随机效应组分析，并使用方差分析（ANOVA）检查牙齿之间的差异。
所有牙齿均双侧激活顶叶岛盖部（S2）；中央后回（S1）在T21和T23时双侧激活，在T11和T13时对侧激活。在包括四颗牙齿的二级分析中，我们发现了五个簇：双侧S1和S2以及左侧额下回，体感区域的牙齿之间无差异。然而，对每颗牙齿分别发现的S1簇进行的方差分析表明，犬齿的S1激活更多为对侧。
1赫兹机械刺激激活牙周机械感受器并在S1和S2中引发双侧皮质活动，在S2中有双重代表，即在OP1和OP4中。
牙周机械感受器的皮质躯体定位描述较少。这些发现可作为正常参考，以进一步探索由牙周或神经系统疾病引起的皮质可塑性。
