Kiguchi Kaoru
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Blvd., Austin, TX, 78723, USA.
J Hepatobiliary Pancreat Sci. 2014 Jun;21(6):371-9. doi: 10.1002/jhbp.66. Epub 2014 Jan 13.
Novel targets for therapeutic or chemopreventive approaches against cholangiocarcinoma (CCA) are urgently needed. In this review article, we discuss the molecular aspects of CCA including the role of erbB receptor tyrosine kinases (RTKs), downstream signaling pathways of these erbB RTKs, inflammatory mediators during gallbladder carcinogenesis and bile acids based on our study using a mouse model for human CCA (BK5.erbB2 mice) as well as additional information in the literature.
迫切需要针对胆管癌（CCA）的治疗或化学预防方法的新靶点。在这篇综述文章中，基于我们使用人CCA小鼠模型（BK5.erbB2小鼠）的研究以及文献中的其他信息，我们讨论了CCA的分子层面，包括erbB受体酪氨酸激酶（RTK）的作用、这些erbB RTK的下游信号通路、胆囊癌变过程中的炎症介质以及胆汁酸。
