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具有非典型表现的胚胎发育不良性神经上皮肿瘤:MRI及弥散张量特征

Dysembryoplastic neuroepithelial tumor with atypical presentation: MRI and diffusion tensor characteristics.

作者信息

Paudel Kalyan, Borofsky Samuel, Jones Robert V, Levy Lucien M

机构信息

Department of Radiology, the George Washington University Hospital, Washington, DC, USA.

Department of Pathology, the George Washington University Hospital, Washington, DC, USA.

出版信息

J Radiol Case Rep. 2013 Nov 1;7(11):7-14. doi: 10.3941/jrcr.v7i11.1559. eCollection 2013 Nov.

Abstract

We report the neuroimaging findings of a 26-year-old female patient with a biopsy-proven dysembryoplastic neuroepithelial tumor (DNET). DNETs are an uncommon, usually benign, glial-neural cortical neoplasm of children and young adults who typically present with intractable seizures. DNETs may occur in any region of the supratentorial cortex, but have a predilection for the temporal lobes. Accurate neuroimaging diagnosis is essential since patients with DNET benefit from complete resection. However, accurate differentiation from other cortical lesions may be challenging. Typical conventional Magnetic Resonance Imaging (MRI) features can help in the differentiation from other similar cortical tumors. Diffusion tensor imaging can also provide important additional diagnostic information regarding the degree of involvement of adjacent parenchyma and white matter tracts. In this case, tractography and fractional anisotropy maps demonstrated that fiber tracts surrounding the lesion were displaced, but fiber integrity was maintained, which is more suggestive of a DNET rather than a more aggressive neoplasm. Accurate identification of DNETs is essential for the purpose of rendering a timely diagnosis and start appropriate treatment.

摘要

我们报告了一名26岁女性患者的神经影像学检查结果,该患者经活检证实患有胚胎发育不良性神经上皮肿瘤(DNET)。DNET是一种罕见的、通常为良性的儿童和青年神经胶质-神经皮质肿瘤,典型表现为顽固性癫痫发作。DNET可发生于幕上皮质的任何区域,但好发于颞叶。准确的神经影像学诊断至关重要,因为DNET患者可从完整切除中获益。然而,与其他皮质病变进行准确鉴别可能具有挑战性。典型的传统磁共振成像(MRI)特征有助于与其他类似的皮质肿瘤进行鉴别。弥散张量成像还可提供有关相邻实质和白质束受累程度的重要额外诊断信息。在该病例中,纤维束成像和分数各向异性图显示病变周围的纤维束移位,但纤维完整性得以维持,这更提示为DNET而非侵袭性更强的肿瘤。准确识别DNET对于及时诊断并开始适当治疗至关重要。

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本文引用的文献

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