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[ABCD3评分在短暂性脑缺血发作后卒中风险预测中的验证]

[Validation of ABCD3 score in the predication of stroke risk after transient ischemic attack].

作者信息

Wang Yuan-yuan, Song Bo, Fang Hui, Zhao Lu, Tan Song, Gao Yuan, Xu Ya-fang, Xu Yu-ming, Sun Shi-lei

机构信息

Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.

Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Email:

出版信息

Zhonghua Yi Xue Za Zhi. 2013 Nov 19;93(43):3424-7.

PMID:24423903

Abstract

UNLABELLED

Objective To explore the evaluation of ABCD(3) score in the prediction of stroke risk after transient ischemic attack and the influencing factors of early stroke risks.

METHODS

From October 2010 to September 2012, the data were prospectively collected from patients with transient ischemic attack according to the World Health Organization time-based criteria. ABCD(2) and ABCD(3) scores were available within 7 days of index transient ischemic attack. The predictive outcome was stroke occurrence at 90 days. Risks of stroke stratified according to the score were analysed by Logistic regression. And ABCD(2) and ABCD(3) model were compared by AUROCC.

RESULTS

Among 321 eligible patients, 4 cases were lost to follow-up. There were 38(11.8%) patients with ischemic stroke during a 90-day follow-up, including 22(57.9%) males, 16(42.1%) females. There were no occurrence of death, no hemorrhagic stroke. Multivariate analysis revealed that dual TIA (OR = 4.116, 95%CI 1.284-3.195) , history of stroke (OR = 4.022, 95%CI 1.472-10.944) and unilateral weakness (OR = 3.117, 95%CI 1.222-7.948) were the risk factors of early stroke. The ABCD(3) score (0.733, 95% CI,0.0.681-0.780) was statistically higher than that of ABCD(2) score (0.674, 95%CI, 0.619-0.725) (P < 0.05).

CONCLUSION

ABCD(3) may effectively predict early risk of stroke after TIA.

摘要

未标注

目的探讨ABCD(3)评分对短暂性脑缺血发作后卒中风险的预测价值及早期卒中风险的影响因素。

方法

2010年10月至2012年9月，根据世界卫生组织基于时间的标准前瞻性收集短暂性脑缺血发作患者的数据。在首次短暂性脑缺血发作后7天内计算ABCD(2)和ABCD(3)评分。预测结局为90天时卒中的发生情况。采用Logistic回归分析根据评分分层的卒中风险。并通过受试者工作特征曲线下面积（AUROCC）比较ABCD(2)和ABCD(3)模型。

结果

321例符合条件的患者中，4例失访。90天随访期间有38例（11.8%）患者发生缺血性卒中，其中男性22例（57.9%），女性16例（42.1%）。无死亡病例，无出血性卒中发生。多因素分析显示，双重短暂性脑缺血发作（OR = 4.116，95%CI 1.284 - 3.195）、卒中病史（OR = 4.022，95%CI 1.472 - 10.944）和单侧肢体无力（OR = 3.117，95%CI 1.222 - 7.948）是早期卒中的危险因素。ABCD(3)评分（0.733，95%CI 0.681 - 0.780）在统计学上高于ABCD(2)评分（0.674，95%CI 0.619 - 0.725）（P < 0.05）。