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ABCD评分能否进行二分法划分,以在急诊科识别短暂性脑缺血发作的高危患者?

Can the ABCD Score be dichotomised to identify high-risk patients with transient ischaemic attack in the emergency department?

作者信息

Bray Janet E, Coughlan Kelly, Bladin Christopher

机构信息

Eastern Melbourne Neurosciences, Box Hill Hospital, Deakin University, Melbourne, Victoria, Australia.

出版信息

Emerg Med J. 2007 Feb;24(2):92-5. doi: 10.1136/emj.2006.041624.

Abstract

BACKGROUND

Recent evidence shows a substantial short-term risk of ischaemic stroke after transient ischaemic attack (TIA). Identification of patients with TIA with a high short-term risk of stroke is now possible through the use of the "ABCD Score", which considers age, blood pressure, clinical features and duration of symptoms predictive of stroke.

AIM

To evaluate the ability of dichotomising the ABCD Score to predict stroke at 7 and 90 days in a population with TIA presenting to an emergency department.

METHODS

A retrospective audit was conducted on all probable or definite TIAs presenting to the emergency department of a metropolitan hospital from July to December 2004. The ABCD Score was applied to 98 consecutive patients with TIA who were reviewed for subsequent strokes within 90 days. Patients obtaining an ABCD Score > or = 5 were considered to be at high risk for stroke.

RESULTS

Dichotomising the ABCD Score categorised 48 (49%) patients with TIA at high risk for stroke (ABCD Score > or = 5). This high-risk group contained all four strokes that occurred within 7 days (sensitivity 100% (95% confidence interval (CI) 40% to 100%), specificity 53% (95% CI 43% to 63%), positive predictive value 8% (95% CI 3% to 21%) and negative predictive value 100% (95% CI 91% to 100%)), and six of seven occurring within 90 days (sensitivity 86% (95% CI 42% to 99%), specificity 54% (95% CI 43% to 64%), positive predictive value 12.5% (95% CI 5% to 26%) and negative predictive value 98% (95% CI 88% to 100%)). Removal of the "age" item from the ABCD Score halved the number of false-positive cases without changing its predictive value for stroke.

CONCLUSION

In this retrospective analysis, dichotomising the ABCD Score was overinclusive but highly predictive in identifying patients with TIA at a high short-term risk of stroke. Use of the ABCD Score in the emergency care of patients with TIA is simple, efficient and provides a unique opportunity to prevent stroke in this population of patients.

摘要

背景

近期证据表明,短暂性脑缺血发作(TIA)后存在显著的短期缺血性卒中风险。通过使用“ABCD评分”,现在可以识别出具有高短期卒中风险的TIA患者,该评分考虑了年龄、血压、临床特征和预测卒中的症状持续时间。

目的

评估将ABCD评分二分法用于预测急诊科就诊的TIA患者在7天和90天时发生卒中的能力。

方法

对2004年7月至12月在一家大城市医院急诊科就诊的所有可能或确诊的TIA患者进行回顾性审计。将ABCD评分应用于98例连续的TIA患者,这些患者在90天内接受了后续卒中检查。ABCD评分≥5分的患者被认为卒中风险高。

结果

将ABCD评分二分法将48例(49%)TIA患者归类为卒中高风险(ABCD评分≥5分)。这个高风险组包含了7天内发生的所有4例卒中(敏感性100%(95%置信区间(CI)40%至100%),特异性53%(95%CI 43%至63%),阳性预测值8%(95%CI 3%至21%),阴性预测值100%(95%CI 91%至100%)),以及90天内发生的7例中的6例(敏感性86%(95%CI 42%至99%),特异性54%(95%CI 43%至64%),阳性预测值12.5%(95%CI 5%至26%),阴性预测值98%(95%CI 88%至100%))。从ABCD评分中去除“年龄”项目可使假阳性病例数减半,而不改变其对卒中的预测价值。

结论

在这项回顾性分析中,将ABCD评分二分法虽涵盖范围过大,但在识别具有高短期卒中风险的TIA患者方面具有高度预测性。在TIA患者的急诊护理中使用ABCD评分简单、有效,并为预防该类患者的卒中提供了独特机会。

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