Goldberg V M, Kresina T F
J Rheumatol. 1987 May;14 Spec No:73-6.
The extracellular matrix of articular cartilage is, in part, comprised of 2 macromolecular moieties, collagen and proteoglycans. This article discusses the role of an autoimmune response to these macromolecules in both inflammatory synovitis and osteoarthritis (OA). Autoimmunity to Type II collagen involving "arthrogenic epitope(s)", expressed on the Type II collagen molecule, as well as cell mediated immune responses to collagen may be relevant in the overall development of destruction of articular cartilage. In OA, a role for inflammation and the immune response to connective tissue macromolecules has been suggested by recent investigations. In this regard, autoimmunity plays a part in the progression of the degeneration of articular cartilage in OA.
关节软骨的细胞外基质部分由两种大分子成分组成，即胶原蛋白和蛋白聚糖。本文讨论了针对这些大分子的自身免疫反应在炎症性滑膜炎和骨关节炎（OA）中的作用。针对II型胶原蛋白的自身免疫反应，涉及II型胶原蛋白分子上表达的“致关节炎表位”，以及对胶原蛋白的细胞介导免疫反应，可能在关节软骨破坏的整体发展过程中发挥作用。在OA中，近期研究表明炎症以及对结缔组织大分子的免疫反应发挥了作用。在这方面，自身免疫在OA关节软骨退变的进展过程中起到一定作用。
