Digestive Oncology Research Center; Digestive Disease Research Institute; Tehran University of Medical Sciences; Tehran, Iran.
Gut Microbes. 2014 Jan-Feb;5(1):11-4. doi: 10.4161/gmic.27291. Epub 2013 Dec 16.
Intestinal homeostasis depends on the proper activity of the intestinal stem cells (ISCs) and an appropriate host response to the normal resident microbiota. The question on the effect of microbiota on ISCs behavior has not been addressed yet. Canonical Wnt pathway and ISC gene expression signature was compared in germfree vs. conventional and MyD88(-/-) vs. Myd88(+/+) mice based on publicly available gene expression data sets. Microbiota and MyD88-dependent signaling have distinct effects on the Wnt pathway and ISC at gene expression level. In addition, the effect of microbiota and MyD88-dependent signaling on Wnt pathway and ISCs show regional variation. The net effect of microbiota on Wnt pathway and ISCs cannot be inferred from the available data. Nonetheless, the data are suggestive of a potential regulatory mechanism of the Wnt pathway by the microbiota and plausibly by any alteration in the microbiota composition.
肠道内稳态依赖于肠道干细胞（ISCs）的正常活性和宿主对正常定植菌群的适当反应。然而，目前尚未研究菌群对 ISC 行为的影响。基于公开的基因表达数据集，比较了无菌与常规以及 MyD88(-/-)与 Myd88(+/+)小鼠之间的经典 Wnt 通路和 ISC 基因表达特征。菌群和 MyD88 依赖性信号对 Wnt 通路和 ISC 在基因表达水平上具有不同的影响。此外，菌群和 MyD88 依赖性信号对 Wnt 通路和 ISCs 的影响存在区域差异。从现有数据中无法推断菌群对 Wnt 通路和 ISCs 的净效应。尽管如此，这些数据提示了菌群通过任何菌群组成的改变可能对 Wnt 通路和 ISCs 具有潜在的调节机制。
