Talathi Nikhil P, Telavane Parag P, Adhikari Devbrata R, Singh Rajinder, Joshi Rajeev M
T. N. Medical College and B. Y. L. Nair Ch. Hospital, Mumbai, India.
T. N. Medical College and B. Y. L. Nair Ch. Hospital, Mumbai, India ; Department of General Surgery, T. N. Medical College & B. Y. L. Nair Ch. Hospital, 504 B, Gold Coin, Tardeo Road, Mumbai, 4000034 India.
Indian J Surg. 2013 Jun;75(Suppl 1):134-40. doi: 10.1007/s12262-012-0530-8. Epub 2012 Jun 8.
Gastrointestinal stromal tumour (GIST) is a soft tissue sarcomas arising from interstitial cell of Cajal of the gastrointestinal tract. Since its description in 1983, its management has seen sea change - from surgery to drug therapy, for CD 117 positive patients. Though it has an indolent course compared to adenocarcinoma, over the decades it has surprised surgeons with its varied presentation. We report a series of 12 cases of GIST. These were evaluated with respect to their age, gender, clinical presentation, histopathology grade, treatment offered & final outcome. There were 7 gastric, 1duodenal, 1 sigmoid, 1 rectal & 2 retroperitoneal GISTs. Resection was carried out for 8 GISTs, 1 was enucleated, 2 are on imatinib therapy & one is under observation. All operated patients had an uneventful post-operative recovery.
胃肠道间质瘤（GIST）是一种起源于胃肠道 Cajal 间质细胞的软组织肉瘤。自 1983 年被描述以来，其治疗方法发生了巨大变化——对于 CD117 阳性患者，从手术治疗转变为药物治疗。尽管与腺癌相比，它的病程较为缓慢，但几十年来，其多样的临床表现一直让外科医生感到惊讶。我们报告了一系列 12 例胃肠道间质瘤病例。对这些病例的年龄、性别、临床表现、组织病理学分级、所接受的治疗及最终结果进行了评估。其中有 7 例胃间质瘤、1 例十二指肠间质瘤、1 例乙状结肠间质瘤、1 例直肠间质瘤和 2 例腹膜后间质瘤。8 例间质瘤进行了切除手术，1 例进行了摘除术，2 例正在接受伊马替尼治疗，1 例正在观察中。所有接受手术的患者术后恢复均顺利。
