Mukherjee Suranjana Sur, Mukherjee Suchandra, Sarkar Kakali Das
Department of Physiology, Nil Ratan Sircar Medical College, Kolkata, India.
Department of Neonatology, Institute of Postgraduate Medical Education and Research (IPGMER), Kolkata, India.
Indian J Otolaryngol Head Neck Surg. 2013 Dec;65(Suppl 3):598-603. doi: 10.1007/s12070-012-0580-z. Epub 2012 Oct 21.
The present study tried to determine the hearing threshold by brainstem evoked response audiometry (BERA) in the high-risk infants from a mediocre socio-economic background at around 1 year of age and correlate different risk factors with hearing loss. BERA was done on 127 infants of 6-18 months age of which 87 were high risk. All were given monaural acoustic stimulus using Cz-M1/M2 Montage. Based on the appearance of wave V at minimum stimulus intensity, hearing threshold in decibels (dB) of each ear was determined. To study the association of the individual risk factor with hearing loss multiple logistic regression test was applied. Taking BERA threshold for 'Pass' as ≤40 dBnHL, out of 87 high risk infants 10.34 % (n = 9) had bilateral severe to profound hearing loss, 17.24 % (n = 15) had bilateral mild to moderate hearing loss and 12.64 % (n = 11) had impaired hearing in one ear. All of the control group infants had normal hearing threshold of 30 dBnHL. Twenty major risk factors were identified in the whole study group at an average of 2.3 factors per infant. Twelve factors were examined for correlation using Odd's ratio (OR) with >40 dBnHL threshold as the outcome variable. Factors with very high OR were family history of deafness, Ototoxic drugs and Cranio-facial abnormality followed by others. High risk infants have a persistent and definitive risk of hearing loss prompting early intervention.
本研究试图通过脑干诱发反应测听法(BERA)测定约1岁时社会经济背景一般的高危婴儿的听力阈值,并将不同风险因素与听力损失相关联。对127名6至18个月大的婴儿进行了BERA测试,其中87名是高危婴儿。所有婴儿均使用Cz-M1/M2导联进行单耳听觉刺激。根据最小刺激强度下V波的出现情况,确定每只耳朵以分贝(dB)为单位的听力阈值。为了研究个体风险因素与听力损失的关联,应用了多元逻辑回归测试。将BERA阈值“通过”设定为≤40dBnHL,在87名高危婴儿中,10.34%(n = 9)有双侧重度至极重度听力损失,17.24%(n = 15)有双侧轻度至中度听力损失,12.64%(n = 11)有单耳听力受损。所有对照组婴儿的听力阈值均正常,为30dBnHL。在整个研究组中确定了20个主要风险因素,平均每个婴儿有2.3个因素。以>40dBnHL阈值作为结果变量,使用优势比(OR)对12个因素进行相关性检验。OR值非常高的因素依次为耳聋家族史、耳毒性药物和颅面畸形等。高危婴儿有持续且明确的听力损失风险,需要早期干预。