瑞香狼毒素B的6,6,5,7-四环核心结构的合成。
Synthesis of the 6,6,5,7-tetracyclic core of daphnilongeranin B.
作者信息
Xiong Xiaochun, Li Yong, Lu Zhaoyong, Wan Ming, Deng Jun, Wu Shuhang, Shao Huawu, Li Ang
机构信息
Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
出版信息
Chem Commun (Camb). 2014 May 25;50(40):5294-7. doi: 10.1039/c3cc47873d. Epub 2014 Jan 15.
An efficient approach toward the synthesis of the 6,6,5,7-tetracyclic core of the daphnilongeranin B, a Daphniphyllum alkaloid, is reported. The bridged 6,6-bicyclic system was constructed using a gold(i) catalysed Conia-ene reaction, while the 5- and 7-membered rings were assembled by two diastereoselective Michael addition reactions, respectively.
报道了一种高效合成瑞香狼毒素B（一种虎皮楠生物碱）的6,6,5,7-四环核心结构的方法。利用金（I）催化的科尼亚-烯反应构建了桥连的6,6-双环体系，而5-元环和7-元环分别通过两个非对映选择性迈克尔加成反应组装而成。
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