Roy A, Virkkunen M, Linnoila M
Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(2-3):173-7. doi: 10.1016/0278-5846(87)90056-x.
We review cerebrospinal fluid (CSF) studies suggesting on association between low CSF levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAAA) and suicidal and impulsive behaviour and alcoholism. Relatively high percentages of alcoholics attempt and commit suicide and have impulsive antisocial personality disorder. Therefore, we suggest that there may be a sizable subgroup of alcoholics who have a reduced central serotonin turnover.
