From the Department of Radiology (P.P.L., S.S.N., J.K.C., R.K.V.) and Division of Dermatology (R.H., R.A.B.), Harbor-UCLA Medical Center, Box 27, 1000 W Carson St, PO Box 2910, Torrance, CA 90509-2910; Department of Family Medicine, USC Keck School of Medicine, Los Angeles, Calif (R.A.B.); and Department of Dermatology, Stanford University School of Medicine, Stanford, Calif (D.H.P.).
Radiographics. 2014 Jan-Feb;34(1):197-216. doi: 10.1148/rg.341125112.
There are a variety of conditions that manifest not only in bone but also in skin. Bone and skin structures can share common embryologic origins, and genetic defects that occur early in cell differentiation may lead to disease in both organ systems. Alternatively, diseases of bone and skin may be caused by defects in genes that participate in directing or controlling both systems. Many diseases of bone and skin can manifest with atypical radiologic findings or mimic malignant bone lesions. Upon encountering such a disease process, a radiologist who is familiar with both aspects of the disorder and consequently looks for associated skin findings can greatly benefit the patient by making a definitive diagnosis. Similarly, a clinician who encounters suggestive skin lesions should be prompted to look for concomitant skeletal lesions. By synthesizing knowledge of bone and skin manifestations, radiologists and clinicians can help correctly diagnose a number of these disease processes, thereby helping patients avoid further, often nonspecific invasive workup and advancing patient care.
有许多种疾病不仅表现在骨骼上，也表现在皮肤上。骨骼和皮肤结构可能具有共同的胚胎起源，并且在细胞分化早期发生的遗传缺陷可能导致两个器官系统都出现疾病。或者，骨骼和皮肤的疾病可能是由于参与指导或控制这两个系统的基因缺陷引起的。许多骨骼和皮肤疾病的影像学表现可能不典型，或模仿恶性骨骼病变。当遇到这样的疾病过程时，熟悉该疾病的两个方面并因此寻找相关皮肤表现的放射科医生可以通过做出明确诊断使患者受益匪浅。同样，遇到提示性皮肤病变的临床医生应该被提示寻找伴随的骨骼病变。放射科医生和临床医生通过综合了解骨骼和皮肤表现，可以帮助正确诊断许多这类疾病过程，从而帮助患者避免进一步进行通常是非特异性的有创检查，并推进患者的治疗。
