Korkuschko O W, Butenko A G, Schatilo W B
Z Gerontol. 1987 May-Jun;20(3):149-53.
The antiarrhythmic efficacy and action of mexitil on minute volume, myocardial function and vegetative regulation of cardiac activity were studied in 25 patients aged 60-89 years, suffering from chronic IHD with stable ventricular extrasystoles. With mexitil dosage of 400-600 mg orally per day there was a marked antiarrhythmic effect in 68% of patients. A similar effect in 64% of patients was observed with a single dose of mexitil (300 mg orally per day) as early as 1-2 h after its administration and maintained for 8-10 h. The above dose of mexitil produced a statistically significant slowing down of cardiac rhythm without changing atrioventricular conductivity. No effect of mexitil on arterial blood pressure was found, nor did it exert cardiodepressive action or any purposeful effect on the vegetative regulation of the heart.
对25例年龄在60 - 89岁、患有慢性缺血性心脏病且伴有稳定室性期前收缩的患者，研究了慢心律对每分输出量、心肌功能及心脏活动自主调节的抗心律失常疗效和作用。每日口服慢心律400 - 600毫克时，68%的患者有明显的抗心律失常作用。单次口服慢心律（每日300毫克）时，早在给药后1 - 2小时，64%的患者就出现类似作用，并持续8 - 10小时。上述剂量的慢心律使心律在统计学上显著减慢，而不改变房室传导。未发现慢心律对动脉血压有影响，也未对心脏自主调节产生心脏抑制作用或任何有针对性的作用。
