Lewandowska M, Paszewski A
Acta Microbiol Pol. 1987;36(1-2):39-51.
Three strains of Cephalosporium acremonium with different potential of cephalosporin C production show differences in the levels of sulphur amino acid metabolic enzymes. The regulation of these enzymes is also different in the strains. In the superior producing strain two enzymes directly involved in cysteine synthesis are the least susceptible to repression by methionine. In this strain cystathionine metabolizing enzymes seem to favour cysteine synthesis. Antibiotic producing strains, in contrast to the non-producing strain, are highly sensitive to chromate.
三株产头孢菌素C潜力不同的顶头孢霉在硫氨基酸代谢酶水平上存在差异。这些酶在菌株中的调控也有所不同。在高产菌株中，直接参与半胱氨酸合成的两种酶对蛋氨酸的阻遏最不敏感。在该菌株中，胱硫醚代谢酶似乎有利于半胱氨酸的合成。与不产抗生素的菌株相比，产抗生素的菌株对铬酸盐高度敏感。
