Decorti G, Klugmann F B, Candussio L, Baldini L
Anticancer Res. 1987 May-Jun;7(3 Pt B):497-9.
The effect of pretreatment with various concentrations of catalase, superoxide-dismutase, D-mannitol, alpha-tocopherol, n-acetylcysteine and reduced glutathione on the release of histamine induced by adriamycin (100 micrograms/ml) on rat peritoneal mast cells was studied. Adriamycin caused an important histamine release in vitro which was not affected by pretreatment with the tested substances. Only n-acetylcysteine, at a very high concentration (1 X 10(-1) M) significantly limited this release. The substance was also active in inhibiting the release induced by a classic mast cell secretagogue, compound 48/80.
研究了用不同浓度的过氧化氢酶、超氧化物歧化酶、D-甘露醇、α-生育酚、N-乙酰半胱氨酸和还原型谷胱甘肽预处理对阿霉素（100微克/毫升）诱导大鼠腹腔肥大细胞释放组胺的影响。阿霉素在体外引起重要的组胺释放，而用受试物质预处理对此没有影响。只有N-乙酰半胱氨酸在非常高的浓度（1×10⁻¹摩尔/升）时能显著限制这种释放。该物质在抑制经典肥大细胞促分泌剂化合物48/80诱导的释放方面也有活性。
