Seki Norio, Sakamoto Setsu, Karube Yoko, Oyaizu Takeshi, Ishihama Hiromi, Chida Masayuki
Department of General Thoracic Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Ann Nucl Med. 2014 Apr;28(3):257-62. doi: 10.1007/s12149-014-0804-2. Epub 2014 Jan 16.
(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) plays an important role in many oncological settings. In this study, we assessed the utility of (18)F-FDG-PET for predicting the histological classification, stage and survival of thymic epithelial tumors.
We retrospectively analyzed 37 patients with thymic epithelial tumors who underwent PET before surgical resection and investigated the relationship between the maximum of standardized uptake value (SUVmax) of each tumor and the WHO classification, recurrence-free survival, and tumor-related gene expressions.
The study included 15 males and 22 females, ranging in age from 22 to 81 years (mean 64 years). The tumor histology of 31 tumors was thymoma and that of the remaining tumors was thymic carcinoma. The Masaoka tumor stage was as follows: stage I in 18, II in 9, III in 5 and IV in 5 patients. The patients were divided into three groups according to a simplified histologic classification: low-risk thymoma (types A, AB and B1, n = 21), high-risk thymoma (types B2 and B3, n = 10) and thymic carcinoma (n = 6). The SUVmax of low-risk group (SUVmax ≤4.27) was significantly lower than that of high-risk group (p = 0.0114) and that of thymic carcinomas (SUVmax >4.27) was also significantly higher than that of thymomas (p < 0.0001). The group of high SUVmax (SUVmax >4.27) had significantly inferior recurrence-free survival to that of less value (SUVmax ≤4.27) (p = 0.0009). The SUVmax were not correlated with tumor-related gene expressions.
The SUVmax of (18)F-FDG-PET reflects WHO classification of thymic epithelial tumors. High SUVmax predicts lower recurrence-free survival of the tumors.
（18）F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）在许多肿瘤学领域发挥着重要作用。在本研究中，我们评估了（18）F-FDG-PET在预测胸腺上皮肿瘤的组织学分类、分期和生存方面的效用。
我们回顾性分析了37例在手术切除前接受PET检查的胸腺上皮肿瘤患者，并研究了每个肿瘤的最大标准化摄取值（SUVmax）与世界卫生组织（WHO）分类、无复发生存率和肿瘤相关基因表达之间的关系。
该研究包括15名男性和22名女性，年龄范围为22至81岁（平均64岁）。31例肿瘤的组织学类型为胸腺瘤，其余肿瘤为胸腺癌。Masaoka肿瘤分期如下：I期18例，II期9例，III期5例，IV期5例。根据简化的组织学分类，患者分为三组：低风险胸腺瘤（A、AB和B1型，n = 21）、高风险胸腺瘤（B2和B3型，n = 10）和胸腺癌（n = 6）。低风险组的SUVmax（SUVmax≤4.27）显著低于高风险组（p = 0.0114），胸腺癌的SUVmax（SUVmax>4.27）也显著高于胸腺瘤（p < 0.0001）。高SUVmax组（SUVmax>4.27）的无复发生存率显著低于低SUVmax组（SUVmax≤4.27）（p = 0.0009）。SUVmax与肿瘤相关基因表达无相关性。
（18）F-FDG-PET的SUVmax反映了胸腺上皮肿瘤的WHO分类。高SUVmax预示着肿瘤较低的无复发生存率。
