Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Kagawa University, Kagawa, Japan.
Eur J Cardiothorac Surg. 2011 Jul;40(1):143-5. doi: 10.1016/j.ejcts.2010.09.009. Epub 2010 Oct 15.
The objective of this study was to investigate whether the maximum standardized uptake value (SUVmax) determined using positron emission tomography with [(18)F]fluoro-2-deoxy-D-glucose ((18)FDG-PET) can predict the grade of malignancy of thymic epithelial tumors based on the World Health Organization (WHO) classification.
We retrospectively analyzed 13 patients with thymic epithelial tumors, who underwent (18)FDG-PET examination before treatment. The patients were subdivided into a thymoma group and a thymic carcinoma group, and the two were compared clinicopathologically.
There were six men and seven women, ranging in age from 36 to 78 years (mean, 58.8 ± 13.3 years). Mean tumor size was 47.3 ± 26.0mm, and the WHO classification was type A in two patients, type AB in none, type B1 in one, type B2 in three, type B3 in two, and thymic carcinoma in five. Thus, eight patients had thymoma and five had thymic carcinoma. The Masaoka stage was I in four patients, II in four, III in three, and IV in two. Mean pre-treatment SUVmax for the tumors overall was 5.24 ± 3.10, with a range of 1.73-11.21. Mean SUVmax in the thymic carcinoma group was 8.15 ± 7.88, and that in the thymoma group was 3.43 ± 2.19, the difference being significant (P = 0.002).
A significant relationship was observed between SUVmax and morphological classification by the WHO system for this cohort of thymic epithelial tumors. Pre-treatment SUVmax may be useful for differentiating thymoma from thymic carcinoma.
本研究旨在探讨正电子发射断层扫描（PET）使用 [(18)F]氟-2-脱氧-D-葡萄糖（FDG-PET）测定的最大标准化摄取值（SUVmax）是否可以根据世界卫生组织（WHO）分类预测胸腺瘤的恶性程度。
我们回顾性分析了 13 例接受治疗前 FDG-PET 检查的胸壁上皮肿瘤患者。将患者分为胸腺瘤组和胸腺癌组，并对两组进行临床病理比较。
患者为 6 名男性和 7 名女性，年龄 36-78 岁，平均年龄 58.8±13.3 岁。肿瘤平均大小为 47.3±26.0mm，WHO 分类为 2 型 A、0 型 AB、1 型 B1、3 型 B2、2 型 B3 和 5 型胸腺癌。因此，8 例为胸腺瘤，5 例为胸腺癌。Masaoka 分期为 4 例 I 期、4 例 II 期、3 例 III 期和 2 例 IV 期。肿瘤总体的平均 SUVmax 为 5.24±3.10，范围为 1.73-11.21。胸腺癌组 SUVmax 为 8.15±7.88，胸腺瘤组 SUVmax 为 3.43±2.19，两组差异有统计学意义（P=0.002）。
在本队列胸壁上皮肿瘤中，SUVmax 与 WHO 形态学分类之间存在显著相关性。SUVmax 可用于区分胸腺瘤和胸腺癌。
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