国际抗癌联盟/美国癌症联合委员会第7版上颌窦癌TNM分类的预后质量

Prognostic quality of the Union Internationale Contre le Cancer/American Joint Committee on Cancer TNM classification, 7th edition, for cancer of the maxillary sinus.

作者信息

Kreppel Matthias, Amir Manawi Nilofar-Natalie, Scheer Martin, Nickenig Hans-Joachim, Rothamel Daniel, Dreiseidler Timo, Drebber Uta, Zinser Max, Zöller Joachim E, Guntinas-Lichius Orlando, Preuss Simon Florian

机构信息

Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany; Center of Integrated Oncology (CIO), Cologne-Bonn, Germany.

出版信息

Head Neck. 2015 Mar;37(3):400-6. doi: 10.1002/hed.23612. Epub 2014 Jun 20.

DOI:10.1002/hed.23612

PMID:24431114

Abstract

BACKGROUND

Carcinomas of the maxillary sinus are classified according to the Union Internationale Contre le Cancer (UICC)/American Joint Committee on Cancer (AJCC) TNM classification. The purpose of this study was to assess the prognostic significance of the UICC/AJCC TNM classification seventh edition, which was introduced in 2010.

METHODS

One hundred thirteen patients with malignant tumors of the maxillary sinus were included in this study. The prognostic impact of the TNM classification and the UICC/AJCC seventh edition's stage grouping were analyzed in univariate and multivariate analysis.

RESULTS

The UICC/AJCC stage grouping, the T classification, and the N classification had a significant impact on overall survival (OS) in univariate analysis (p < .05). No significant differences were observed between the groups T4a and T4b (p = .109). In multivariate analysis, the UICC/AJCC stage grouping (p = .031), the N classification (p = .014), and age (p < .001) had a significant impact on OS.

CONCLUSION

Although UICC/AJCC stage grouping and the N classification provided a significant prediction of OS in univariate and multivariate analysis, T classification only influenced OS in univariate analysis.

摘要

背景

上颌窦癌依据国际抗癌联盟（UICC）/美国癌症联合委员会（AJCC）的TNM分类进行分类。本研究的目的是评估2010年引入的UICC/AJCC TNM分类第七版的预后意义。

方法

本研究纳入了113例上颌窦恶性肿瘤患者。在单因素和多因素分析中分析了TNM分类和UICC/AJCC第七版分期分组的预后影响。

结果

在单因素分析中，UICC/AJCC分期分组、T分类和N分类对总生存期（OS）有显著影响（p < 0.05）。T4a组和T4b组之间未观察到显著差异（p = 0.109）。在多因素分析中，UICC/AJCC分期分组（p = 0.031）、N分类（p = 0.014）和年龄（p < 0.001）对OS有显著影响。