以神经甾体生物合成作为创伤后应激障碍的治疗靶点。 - Suppr

Suppr

超能文献

Targeting neurosteroidogenesis as therapy for PTSD.

作者信息

Pinna Graziano

机构信息

Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago Chicago, IL, USA.

出版信息

Front Pharmacol. 2014 Jan 6;4:166. doi: 10.3389/fphar.2013.00166.

DOI:10.3389/fphar.2013.00166

PMID:24432002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3880842/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ddb/3880842/61cf69abfb53/fphar-04-00166-g0001.jpg

相似文献

Targeting neurosteroidogenesis as therapy for PTSD.以神经甾体生物合成作为创伤后应激障碍的治疗靶点。

Front Pharmacol. 2014 Jan 6;4:166. doi: 10.3389/fphar.2013.00166.

Repeated administration of AC-5216, a ligand for the 18 kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder.反复给予 18 kDa 转位蛋白配体 AC-5216 可改善创伤后应激障碍小鼠模型的行为缺陷。

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:40-6. doi: 10.1016/j.pnpbp.2013.04.010. Epub 2013 Apr 23.

Neuroactive steroids and PTSD treatment.神经活性甾体与创伤后应激障碍的治疗

Neurosci Lett. 2017 May 10;649:156-163. doi: 10.1016/j.neulet.2017.01.054. Epub 2017 Feb 12.

A randomized controlled trial of ganaxolone in posttraumatic stress disorder.甘氨酰胺酮治疗创伤后应激障碍的一项随机对照试验。

Psychopharmacology (Berl). 2017 Aug;234(15):2245-2257. doi: 10.1007/s00213-017-4649-y. Epub 2017 Jul 1.

Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells.神经细胞中通过膜孕激素受体（PAQRs）介导的孕烷醇酮和甘烷醇酮的抗细胞凋亡作用。

Front Endocrinol (Lausanne). 2020 Jun 24;11:417. doi: 10.3389/fendo.2020.00417. eCollection 2020.

Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.别孕烯醇酮参与AC-5216的抗创伤后应激障碍样效应。

J Psychopharmacol. 2016 May;30(5):474-81. doi: 10.1177/0269881115625115. Epub 2016 Jan 18.

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.肌内注射别孕烯醇酮和 ganaxolone 治疗耐药性癫痫持续状态的小鼠模型。

Epilepsia. 2018 Oct;59 Suppl 2(Suppl 2):220-227. doi: 10.1111/epi.13999. Epub 2018 Feb 17.

Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD.创伤后应激障碍男性患者脑脊液 GABA 能神经甾体水平与症状严重程度的关系。

Psychoneuroendocrinology. 2019 Apr;102:95-104. doi: 10.1016/j.psyneuen.2018.11.027. Epub 2018 Nov 22.

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma.女性创伤后应激障碍与血浆中孕激素向 GABA 能神经甾体别孕烯醇酮和孕烷醇酮转化受阻有关。

Psychoneuroendocrinology. 2018 Jul;93:133-141. doi: 10.1016/j.psyneuen.2018.04.024. Epub 2018 Apr 24.

Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder.创伤后应激障碍女性脑脊液中别孕烯醇酮水平降低。

Biol Psychiatry. 2006 Oct 1;60(7):704-13. doi: 10.1016/j.biopsych.2006.03.026. Epub 2006 Aug 24.

引用本文的文献

Neuroactive steroids and the pathophysiology of PTSD: Biomarkers for treatment targeting.神经活性甾体与创伤后应激障碍的病理生理学：靶向治疗的生物标志物

Neurosci Biobehav Rev. 2025 May;172:106085. doi: 10.1016/j.neubiorev.2025.106085. Epub 2025 Feb 28.

Editorial: Steroids and the Brain.社论：类固醇与大脑

Front Endocrinol (Lausanne). 2020 Jun 3;11:366. doi: 10.3389/fendo.2020.00366. eCollection 2020.

Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?别孕烯醇酮，从神经调节剂转变为治疗剂：下一个是什么？

Front Endocrinol (Lausanne). 2020 May 14;11:236. doi: 10.3389/fendo.2020.00236. eCollection 2020.

Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone.创伤后应激障碍的动物模型：社会隔离小鼠与别孕烯醇酮的生物标志物作用

Front Behav Neurosci. 2019 Jun 11;13:114. doi: 10.3389/fnbeh.2019.00114. eCollection 2019.

Biomarkers for PTSD at the Interface of the Endocannabinoid and Neurosteroid Axis.创伤后应激障碍在内源性大麻素与神经甾体轴交界处的生物标志物

Front Neurosci. 2018 Aug 6;12:482. doi: 10.3389/fnins.2018.00482. eCollection 2018.

Neurosteroid biosynthesis down-regulation and changes in GABA receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.神经甾体生物合成下调和 GABA 受体亚基组成变化：应激诱导的认知和情绪障碍的生物标志物轴。

Br J Pharmacol. 2017 Oct;174(19):3226-3241. doi: 10.1111/bph.13843. Epub 2017 Jun 14.

Brain and Serum Androsterone Is Elevated in Response to Stress in Rats with Mild Traumatic Brain Injury.轻度创伤性脑损伤大鼠对应激的反应中，脑和血清中的雄酮水平升高。

Front Neurosci. 2016 Aug 26;10:379. doi: 10.3389/fnins.2016.00379. eCollection 2016.

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research.当今的神经甾体生成：神经活性甾体合成与作用的新靶点及其与转化研究的相关性

J Neuroendocrinol. 2016 Feb;28(2):12351. doi: 10.1111/jne.12351.

Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator.新型γ-氨基丁酸A型受体阳性变构调节剂对脆性X综合征Fmr-/y小鼠模型中杏仁核紧张性γ-氨基丁酸能电流缺陷的挽救作用

J Neurosci Res. 2016 Jun;94(6):568-78. doi: 10.1002/jnr.23632. Epub 2015 Aug 26.

Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats.终纹床核中的别孕烯醇酮调节大鼠的情境性恐惧。

Front Behav Neurosci. 2015 Aug 4;9:205. doi: 10.3389/fnbeh.2015.00205. eCollection 2015.

本文引用的文献

SSRIs and the female brain--potential for utilizing steroid-stimulating properties to treat menstrual cycle-linked dysphorias.SSRIs 和女性大脑——利用类固醇刺激特性治疗与月经周期相关的心境恶劣障碍的潜力。

J Psychopharmacol. 2013 Dec;27(12):1180-5. doi: 10.1177/0269881113490327. Epub 2013 May 23.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:40-6. doi: 10.1016/j.pnpbp.2013.04.010. Epub 2013 Apr 23.

Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder.上调神经甾体生物合成作为一种改善创伤后应激障碍潜在小鼠模型行为缺陷的药理学策略。

J Neuroendocrinol. 2012 Jan;24(1):102-16. doi: 10.1111/j.1365-2826.2011.02234.x.

Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD).创伤后应激障碍（PTSD）的循证药物治疗。

Int J Neuropsychopharmacol. 2012 Jul;15(6):825-40. doi: 10.1017/S1461145711001209. Epub 2011 Jul 29.

Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?神经活性甾体在情感障碍中的作用：新型抗抑郁或抗焦虑药物的作用靶点？

Neuroscience. 2011 Sep 15;191:55-77. doi: 10.1016/j.neuroscience.2011.03.025. Epub 2011 Mar 23.

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders.转位蛋白（18kDa）（TSPO）作为神经和精神疾病的治疗靶点。

Nat Rev Drug Discov. 2010 Dec;9(12):971-88. doi: 10.1038/nrd3295.

S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice.S-氟西汀微量注入外侧杏仁核会增加别孕烯醇酮的水平，并减少社交隔离小鼠的攻击行为。

Neuropharmacology. 2011 Jun;60(7-8):1154-9. doi: 10.1016/j.neuropharm.2010.10.011. Epub 2010 Oct 29.

In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis.在一种与创伤后应激障碍相关的小鼠模型中，选择性脑甾体生成刺激剂（SBSS）通过使别孕烷醇酮生物合成正常化来改善行为缺陷。

Behav Pharmacol. 2010 Sep;21(5-6):438-50. doi: 10.1097/FBP.0b013e32833d8ba0.

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.转运蛋白（18kD）作为无苯二氮䓬类副作用的抗焦虑药靶点。

Science. 2009 Jul 24;325(5939):490-3. doi: 10.1126/science.1175055. Epub 2009 Jun 18.

Pregnanolone sulfate promotes desensitization of activated NMDA receptors.硫酸孕烷醇酮可促进活化的N-甲基-D-天冬氨酸受体脱敏。

J Neurosci. 2009 May 27;29(21):6819-27. doi: 10.1523/JNEUROSCI.0281-09.2009.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验