威克汉姆原藻血症在一名系统性红斑狼疮患者中表现为胆汁淤积性肝炎：病例报告及文献综述
Prototheca wickerhamii algaemia presenting as cholestatic hepatitis in a patient with systemic lupus erythematosus: A case report and literature review.
作者信息
Min Zaw, Moser Stephen A, Pappas Peter G
机构信息
Division of Infectious Diseases, University of Alabama at Birmingham, THT 229, 1530 3rd Avenue South, Birmingham, AL 35294-0006, USA.
Department of Pathology, Division of Laboratory Medicine, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL 35249-7331, USA.
出版信息
Med Mycol Case Rep. 2012 Dec 20;2:19-22. doi: 10.1016/j.mmcr.2012.12.004.
Abstract
Human protothecal infection is uncommon and could be localized or systemic disease. Disseminated Prototheca algaemia tends to occur in immunocompromised patients (solid organ transplants, hematological malignancies) with high mortality. Diagnosis could be missed or delayed due to unusual clinical presentation and/or under-recognition of characteristic microscopic features of Prototheca species. Combined approach that includes removal of source of infection and intravenous amphotericin B provides the best chance of cure.
摘要
人类原藻感染并不常见，可为局部或全身性疾病。播散性原藻血症往往发生在免疫功能低下的患者（实体器官移植、血液系统恶性肿瘤）中，死亡率很高。由于临床表现不寻常和/或对原藻属物种特征性微观特征认识不足，诊断可能会被漏诊或延误。包括去除感染源和静脉注射两性霉素B在内的联合治疗方法提供了最佳的治愈机会。
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