Mavrina E S, Garmaeva T Ts, Troitskaia V V, Makhinia S A, Glinshchikova O A, Biriukova L S, Mikhaĭlova E A, Parovichnikova E N, Savchenko V G
Ter Arkh. 2013;85(11):69-72.
Having a tropism for erythroid progenitor cells, parvovirus B19 may cause partial red cell aplasia and thrombocytopenia. Early diagnosis of parvovirus B19 infection in immunocompromised patients is needed for timely antiviral therapy. A high-risk group for parvovirus B19 infection includes patients with blood diseases who receive multiple transfusions of blood components; those who have undergone donor organ transplantation and are long taking immunosuppressive drugs; and pregnant women. These patients require careful virological monitoring for major blood-borne viral infections. This paper describes a clinical case of parvovirus B19 infection in a pregnant woman who has undergone kidney transplantation and is continuously taking immunosuppressive medications. Identification of the cause of severe anemia and timely adequate therapy could lead to the recovery of effective erythropoiesis in the patient.
细小病毒B19对红系祖细胞具有嗜性，可能导致部分红细胞再生障碍和血小板减少。免疫功能低下患者需要早期诊断细小病毒B19感染以便及时进行抗病毒治疗。细小病毒B19感染的高危人群包括接受多次血液成分输血的血液病患者；接受供体器官移植且长期服用免疫抑制药物的患者；以及孕妇。这些患者需要对主要血源病毒感染进行仔细的病毒学监测。本文描述了一例肾移植术后持续服用免疫抑制药物的孕妇感染细小病毒B19的临床病例。明确严重贫血的病因并及时进行充分治疗可使患者有效红细胞生成恢复。
