Svartholm E, Bergqvist D, Haglund U, Ljungberg J, Hedner U
Lund University, Department of Surgery, Malmö General Hospital, Sweden.
Circ Shock. 1987;22(4):291-301.
The aim of this study was to investigate the influence on various hemostatic factors (alpha 2-macroglobulin, antiplasmin, antithrombin III, prothrombin-proconvertin activity, fibrinogen concentration, ethanol gelation test, and fibrinolytic activity on fibrin plates) of bacteremic shock in swine and the influence on these factors of drugs interfering with platelet function. Anesthetized pigs were given live Escherichia coli intravenously (n = 49) or Ringer's solution (n = 7) and were monitored for 3 hours. Pretreatment was given with indomethacin (n = 6), the TxA2 inhibitor UK 38 485 (n = 7), the prostacyclin analogue ZK 36 374 (n = 7), the 5HT antagonist ketanserin (n = 6), or ketanserin combined with UK 38 485 (n = 9) or dipyridamole (n = 8). Septic shock developed in all E. coli animals. There were decreased levels of platelets and leukocytes and activation of the coagulation/fibrinolytic systems by E. coli. Except for a slight attenuating effect on the antithrombin III (ketanserin and dipyridamole) and alpha 2-macroglobulin (ketanserin) decreases, there were no significant effects of the drugs. It is concluded that live E. coli induced several changes within the coagulation and fibrinolytic systems. Only minor effects were seen when different drugs influencing platelet function were given.
本研究旨在调查猪败血症休克对各种止血因子（α2-巨球蛋白、抗纤溶酶、抗凝血酶III、凝血酶原-凝血酶原转变加速因子活性、纤维蛋白原浓度、乙醇凝胶试验以及纤维蛋白平板上的纤溶活性）的影响，以及干扰血小板功能的药物对这些因子的影响。对麻醉的猪静脉注射活的大肠杆菌（n = 49）或林格氏液（n = 7），并监测3小时。预先给予吲哚美辛（n = 6）、血栓素A2抑制剂UK 38 485（n = 7）、前列环素类似物ZK 36 374（n = 7）、5-羟色胺拮抗剂酮色林（n = 6），或酮色林与UK 38 485联合使用（n = 9）或双嘧达莫（n = 8）。所有注射大肠杆菌的动物均发生感染性休克。大肠杆菌导致血小板和白细胞水平降低，并激活凝血/纤溶系统。除了对凝血酶III降低（酮色林和双嘧达莫）和α2-巨球蛋白降低（酮色林）有轻微的减弱作用外，这些药物没有显著影响。得出的结论是，活的大肠杆菌在凝血和纤溶系统内引起了几种变化。给予影响血小板功能的不同药物时，仅观察到轻微影响。
