Movement Disorders Section, Department of Neurology, Hannover Medical School, Hannover, Germany.
Eur J Neurol. 2014 Mar;21(3):459-62. doi: 10.1111/ene.12330. Epub 2014 Jan 16.
Conventional scales measure the effect of botulinum toxin (BT) therapy only at specific points in time. The Dystonia Discomfort Scale (DDS), a novel, easy-to-use, self-assessment scale to record temporal profiles of the effect of BT therapy in cervical dystonia (CD), is introduced and evaluated against the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS).
Seventy-six patients with CD (age 54.4 ± 10.9 years, 34% male) receiving ≤5 cycles of incobotulinumtoxinA (Xeomin); Merz Pharmaceuticals, Frankfurt am Main, Germany) injections at intervals ≥10 weeks used DDS to record the severity of their symptoms daily. DDS data were compared with TWSTRS-Total scores and patients' subjective estimation (SE) of the onset (TO) and waning (TW) of the treatment effect.
The Toronto Western Spasmodic Torticollis Rating Scale - Total scores correlated significantly with DDS (P ≤ 0.028 at all visits evaluated). TO-DDS and TO-SE were 7.9 ± 8.6 and 7.1 ± 4.1 days, respectively; TW-DDS and TW-SE were 41.8 ± 19.2 and 45.1 ± 21.5 days, respectively.
The Dystonia Discomfort Scale is a novel, easy-to-use, self-assessment scale for valid and sensitive monitoring of the temporal profile of the effect of BT therapy in patients with CD. DDS provides important additional information about onset, duration, waning, stability and reproducibility of the effects of BT therapy.
传统量表仅在特定时间点测量肉毒毒素（BT）治疗的效果。Dystonia Discomfort Scale（DDS）是一种新的、易于使用的自我评估量表，用于记录颈肌张力障碍（CD）患者 BT 治疗效果的时间曲线，本文旨在评估其与多伦多西部痉挛性斜颈评定量表（TWSTRS）的相关性。
76 例接受≤5 个周期的依酚氯铵毒素 A（Xeomin；德国法兰克福 Merz 制药公司）注射治疗的 CD 患者（年龄 54.4±10.9 岁，34%为男性），注射间隔≥10 周，使用 DDS 每日记录其症状严重程度。将 DDS 数据与 TWSTRS 总分和患者对治疗效果开始（TO）和消退（TW）的主观估计（SE）进行比较。
多伦多西部痉挛性斜颈评定量表总分与 DDS 显著相关（所有评估访视点 P≤0.028）。TO-DDS 和 TO-SE 分别为 7.9±8.6 和 7.1±4.1 天；TW-DDS 和 TW-SE 分别为 41.8±19.2 和 45.1±21.5 天。
Dystonia Discomfort Scale 是一种新的、易于使用的自我评估量表，用于有效且敏感地监测 CD 患者 BT 治疗效果的时间曲线。DDS 提供了关于 BT 治疗效果的开始、持续时间、消退、稳定性和可重复性的重要补充信息。
