Hamoen Esther H J, De Rooij Maarten, Witjes J Alfred, Barentsz Jelle O, Rovers Maroeska M
Department of Urology, Radboud University Nijmegen Medical Centre, The Netherlands; Department of Radiology, Radboud University Nijmegen Medical Centre, The Netherlands.
Department of Radiology, Radboud University Nijmegen Medical Centre, The Netherlands; Department of Operating Rooms, Radboud University Nijmegen Medical Centre, The Netherlands.
Urol Oncol. 2015 Feb;33(2):69.e19-28. doi: 10.1016/j.urolonc.2013.10.005. Epub 2014 Jan 13.
To identify and study the psychometric properties of the most used health-related quality-of-life (HRQoL) instruments in men with prostate cancer.
We performed a literature search using PubMed and EMBASE to identify all studies on prostate cancer using a HRQoL instrument. The most often used HRQoL instruments were investigated in detail by 2 independent reviewers. Data were extracted regarding the characteristics and psychometric values of the instruments, i.e., content validity, internal consistency, criterion validity, construct validity, reproducibility, responsiveness, floor and ceiling effects, and interpretability. Good psychometric outcomes indicate a high methodological quality of the instrument.
Our systematic search revealed 13,812 potential relevant articles, of which 2,258 appeared relevant after screening the titles and reading the abstracts. We studied the psychometric properties of the 20 most often used HRQoL instruments, the first 3 of which were the Expanded Prostate Index Composite, University of California-Los Angeles Prostate Cancer Index, and Short Form-36 (SF-36). Content validity, internal consistency (α>0.70), criterion validity, construct validity, and reproducibility were good in 60%, 90%, 10%, 35%, and 65% of the 20 instruments, respectively. Responsiveness was not reported for 12 of 20 instruments (60%). Floor and ceiling effects and the interpretability of the questionnaires were only reported in 3 (15%) and 6 (30%) instruments.
Considering the psychometric properties, we advise to use the SF-12 as a generic instrument, the Cancer Rehabilitation Evaluation System-SF or the Functional Assessment of Cancer Therapy-General as cancer-specific HRQoL instruments, and the University of California-Los Angeles Prostate Cancer Index, the QUFW94, or the Functional Assessment of Cancer Therapy-Prostate as prostate cancer-specific instruments.
识别并研究前列腺癌男性中最常用的健康相关生活质量（HRQoL）工具的心理测量特性。
我们使用PubMed和EMBASE进行文献检索，以识别所有使用HRQoL工具的前列腺癌研究。2名独立评审员对最常用的HRQoL工具进行了详细调查。提取了有关工具的特征和心理测量值的数据，即内容效度、内部一致性、效标效度、结构效度、可重复性、反应性、地板效应和天花板效应以及可解释性。良好的心理测量结果表明该工具具有较高的方法学质量。
我们的系统检索共发现13812篇潜在相关文章，其中2258篇在筛选标题和阅读摘要后显得相关。我们研究了20种最常用的HRQoL工具的心理测量特性，其中前3种是扩展前列腺指数综合量表、加利福尼亚大学洛杉矶分校前列腺癌指数和简短健康调查简表（SF-36）。在这20种工具中，分别有60%、90%、10%、35%和65%的工具具有良好的内容效度、内部一致性（α>0.70）、效标效度、结构效度和可重复性。20种工具中有12种（60%）未报告反应性。仅3种（15%）和6种（30%）工具报告了地板效应和天花板效应以及问卷的可解释性。
考虑到心理测量特性，我们建议使用SF-12作为通用工具，癌症康复评估系统简表或癌症治疗功能评估通用量表作为癌症特异性HRQoL工具，以及加利福尼亚大学洛杉矶分校前列腺癌指数、QUFW94或癌症治疗功能评估前列腺量表作为前列腺癌特异性工具。
