Haraldsdottir Sigurdis, Hampel Heather, Wei Lai, Wu Christina, Frankel Wendy, Bekaii-Saab Tanios, de la Chapelle Albert, Goldberg Richard M
Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA.
Division of Human Genetics, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA.
Genet Med. 2014 Jul;16(7):553-7. doi: 10.1038/gim.2013.193. Epub 2014 Jan 16.
An increased risk of prostate cancer is currently not considered a part of the Lynch syndrome spectrum. The purpose of this study was to retrospectively examine prostate cancer incidence in the Lynch syndrome cohort at the Ohio State University in comparison with that in the general population.
We included all males diagnosed with Lynch syndrome from June 1998 to June 2012 at the Ohio State University and obtained baseline information including cancer history. If patients had not been seen in the 12 months before June 2012, they were contacted to document changes in their cancer history. We compared prostate cancer incidence among the Lynch syndrome families with that of the general population by using the Surveillance, Epidemiology, and End RESULTS registry 1999-2009.
Of the 188 males identified with Lynch syndrome, 11 males were diagnosed with prostate cancer during the study period. The ratio of observed to expected numbers of prostate cancer cases resulted in a standardized rate ratio of 4.87 (95% confidence interval: 2.43-8.71). Impaired mismatch repair expression and microsatellite instability were seen in one out of two prostate cancer specimens available for testing.
Males with Lynch syndrome had a nearly fivefold increased risk of developing prostate cancer but did not appear to have earlier onset or a more aggressive phenotype.
目前前列腺癌风险增加不被视为林奇综合征谱系的一部分。本研究的目的是回顾性研究俄亥俄州立大学林奇综合征队列中前列腺癌的发病率，并与普通人群进行比较。
我们纳入了1998年6月至2012年6月在俄亥俄州立大学被诊断为林奇综合征的所有男性，并获取了包括癌症病史在内的基线信息。如果患者在2012年6月前的12个月内未就诊，则与他们联系以记录其癌症病史的变化。我们使用1999 - 2009年监测、流行病学和最终结果登记处的数据，比较了林奇综合征家族中前列腺癌的发病率与普通人群的发病率。
在188名确诊为林奇综合征的男性中，有11名男性在研究期间被诊断出患有前列腺癌。观察到的前列腺癌病例数与预期病例数之比得出标准化发病率比为4.87（95%置信区间：2.43 - 8.71）。在可供检测的两份前列腺癌标本中，有一份出现错配修复表达受损和微卫星不稳定。
患有林奇综合征的男性患前列腺癌的风险增加了近五倍，但似乎没有更早发病或更具侵袭性的表型。
