Department of Diabetes and Endocrinology, Derby Hospitals NHS FT, Derby, UK.
Nephron Clin Pract. 2014;126(1):14-8. doi: 10.1159/000357680. Epub 2014 Jan 11.
One of the commonest complications of type 2 diabetes is renal disease. Treatment guidelines emphasise the need for tight glycaemic control to reduce the development of future complications; however, with the development of renal impairment, the benefit of tight glycaemic control must be weighed against the potential for adverse effects from drugs or their metabolites which may accumulate. In this article, the glucose-lowering drugs used in the management of type 2 diabetes are reviewed, with particular emphasis on newer guidelines and agents.
2 型糖尿病常见的并发症之一是肾脏疾病。治疗指南强调需要严格控制血糖，以减少未来并发症的发生；然而，随着肾功能损害的发展，必须权衡严格血糖控制的益处与药物或其代谢物可能积聚带来的潜在不良反应。本文回顾了用于 2 型糖尿病管理的降糖药物，特别强调了新的指南和药物。
