Department of Statistics and Computer Science, Kansas State University, Manhattan, USA.
Theor Appl Genet. 1970 Jan;40(6):245-50. doi: 10.1007/BF00282033.
A genetic model of a two allelic locus involving gene frequency dependent selection with overdominance or underdominance was investigated with regard to the probability of and the expected time to fixation of an allele in the face of stochastic variations arising from finite population size. Results showed the following: 1. If the probability of fixation is larger than for no selection, the case of fequency dependent selection with overdominance at equilibrium gave rise to the highest probability of fixation. If, however, the probability of fixation is less than for no selection, the case of frequency dependent selection and underdominance at equilibrium gives rise to the highest probability of fixation. 2. The expected time to fixation is largest for the case of overdominance at equilibrium and smallest for the case of underdominance at equilibrium if 0.2< p < 0.8. 3. For equilibrium gene frequencies (p) above 0.8 or below 0.2 there was acceleration in the time to fixation. This acceleration occurred over a wide range of initial gene frequencies that includes the p value.
建立了一个涉及基因频率依赖选择的双等位基因座遗传模型，其中包括超显性或劣势显性。研究了在由有限种群大小引起的随机变化的情况下，等位基因固定的概率和预期时间。结果表明：1. 如果固定的概率大于无选择，则平衡时的超显性频率依赖选择会导致固定的概率最高。然而，如果固定的概率小于无选择，则平衡时的劣势频率依赖选择会导致固定的概率最高。2. 平衡时超显性的固定预期时间最大，平衡时劣势的固定预期时间最小，如果 0.2< p < 0.8。3. 对于平衡基因频率（p）高于 0.8 或低于 0.2，固定时间会加速。这种加速发生在一个包括 p 值在内的广泛的初始基因频率范围内。
