Minvielle F
Genetics. 1980 Apr;94(4):989-1000. doi: 10.1093/genetics/94.4.989.
A quantitative character controlled at one locus with two alleles was submitted to artificial (mass) selection and to three modes of opposing natural selection (directional selection, overdominance and underdominance) in a large random-mating population. The selection response and the limits of the selective process were studied by deterministic simulation. The lifetime of the process was generally between 20 and 100 generations and did not appear to depend on the mode of natural selection. However, depending on the values of the parameters (initial gene frequency, selection intensity, ratio of the effect of the gene to the environmental standard deviation, fitness values) the following outcomes of selection were observed: fixation of the allele favored by artificial selection, stable nontrivial equilibrium, unstable equilibrium and loss of the allele favored by artificial selection. Finally, the results of the simulation were compared to the results of selection experiments.
一个由一个位点控制、具有两个等位基因的数量性状，在一个大型随机交配群体中接受人工（群体）选择以及三种相反的自然选择模式（定向选择、超显性和亚显性）。通过确定性模拟研究了选择反应和选择过程的极限。该过程的持续时间通常在20到100代之间，并且似乎不依赖于自然选择模式。然而，根据参数值（初始基因频率、选择强度、基因效应与环境标准差的比率、适合度值），观察到了以下选择结果：人工选择所青睐的等位基因固定、稳定的非平凡平衡、不稳定平衡以及人工选择所青睐的等位基因丢失。最后，将模拟结果与选择实验结果进行了比较。
