变应性鼻炎患者患鼻咽癌的后续风险：一项基于全国人群的队列研究。
Subsequent risk of nasopharyngeal carcinoma among patients with allergic rhinitis: a nationwide population-based cohort study.
作者信息
Lin Kuen-Tze, Huang Wen-Yen, Lin Che-Chen, Jen Yee-Min, Lin Chun-Shu, Lo Cheng-Hsiang, Kao Chia-Hung
机构信息
Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
出版信息
Head Neck. 2015 Mar;37(3):413-7. doi: 10.1002/hed.23617. Epub 2014 Apr 9.
BACKGROUND
The purpose of this study was to examine the risk of nasopharyngeal carcinoma (NPC) after a diagnosis of allergic rhinitis.
METHODS
We identified 67,532 patients with allergic rhinitis (allergic rhinitis cohort) and a 135,064 control cohort with the same mean age and sex ratio by using a Taiwan Longitudinal Health Insurance Database (LHID) sample from 2000 to 2005.
RESULTS
After adjusting for the possible confounding factors of the study, the allergic rhinitis cohort had a 2.33-fold higher risk of developing NPC than did the comparison cohort. The frequency of allergic rhinitis visits was correlated with the risk of subsequent NPC. Patients with 4 or more allergic rhinitis visits per year were significantly associated with increasingly developing NPC risk.
CONCLUSION
Patients with allergic rhinitis might be associated with subsequent NPC in Taiwan. Those who had repeated visits for allergic rhinitis had even higher risk for NPC. Physicians should be aware of the link when assessing patients with allergic rhinitis.
背景
本研究旨在探讨诊断为过敏性鼻炎后发生鼻咽癌（NPC）的风险。
方法
我们使用2000年至2005年台湾纵向健康保险数据库（LHID）样本，确定了67532例过敏性鼻炎患者（过敏性鼻炎队列）和135064例年龄均值和性别比例相同的对照队列。
结果
在对研究中可能的混杂因素进行调整后，过敏性鼻炎队列发生鼻咽癌的风险比对照队列高2.33倍。过敏性鼻炎就诊频率与随后发生鼻咽癌的风险相关。每年有4次或更多次过敏性鼻炎就诊的患者与鼻咽癌发生风险增加显著相关。
结论
在台湾，过敏性鼻炎患者可能与随后发生的鼻咽癌有关。那些因过敏性鼻炎反复就诊的患者患鼻咽癌的风险更高。医生在评估过敏性鼻炎患者时应注意这种关联。
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